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GENTAUR France SARL

Rue Lagrange, 9

75005 Paris, France

 01 43 25 01 50

 

GENTAUR Germany

IME, Frockenbeckstrasse 6

52074 Aachen, Germany

 +32 1658 9045

 

GENTAUR Italy

23015 Milano, Italy

 02 36 00 65 93

 

 

 

Europe

 

Česká republika Praha
+420246019719

 

Danmark

+4569918806

 

Finland Helsset
+358942419041

 

Ελλάς Αθήνα
+302111768494

 

Ireland Dublin
+35316526556

 

Luxembourg
+35220880274

 

Magyarország Budapest
+3619980547

 

Nederland
+31208080893

 

Norge Oslo
+4721031366

 

Österreich
+43720880899

 

Sverige Stockholm
+46852503438

 

Schweiz Züri
+41435006251

 

 

Northern America

 

Canada Montreal
+15149077481

 

US New York
+17185132983

 

 

Asia

 

日本
 +81 78 386 0860

Other Countries
0032 (0)16 41 44 07

 

 

PARP Pharmacodynamic Assay

PARP catalyzes the NAD-dependent addition of poly (ADP-ribose) (PAR) onto itself and adjacent nuclear proteins. Furthermore, polymorphisms in the PARP-1 gene correspond to disease predisposition, and variation in PARP activity might have an impact on the effects of PARP inhibitors in clinical settings. To address the need to monitor PARP activity among different individuals, and within cells, validated PARP in vivo Pharmacodynamic Assay measures net PAR levels in cellular extracts and has been used to document differences in PAR levels among tumor lysates from different tissues, organs and xenografts.

 Features

·     Chemiluminescent, non-radioactive format

·     Higher throughput, 96 test size

·     Sensitivity down to 10 pg/ml of PAR

 Applications

·     Quantification of PAR in peripheral blood mononuclear cells and tissue culture cells

·     Monitoring the efficacy of PARP inhibitors on cellular PAR formation

·     Verifying observations of enhanced cancer cell cytotoxicity arising from PARP inhibitor/anticancer drug combination

      therapy.

 

Code Product Name Quantity Price
4510-096-K PARP in vivo Pharmacodynamic Assay 1x 96 well 1269€
4690-096-K HT Fluorescent Homogen. PARP Inhibition Assay 1x 96 well 489€
4684-096-K HT Colorimetric PARP/Apoptosis Assay 1x 96 well 533€
4685-096-K HT Chemiluminescent PARP/Apoptosis Assay 1x 96 well 533€

Centrifuge Tubes

 

·    RACKED

·    Sterile

Text Box: 50 mL & 15 mL

 

·    Non-Pyrogenic

·    Polypropylene

·    Flat-Top, Screw-on Caps

·    Conical Bottoms

·    White, Easy to Read, Printed Graduations

·    White Writing Area, for Easy Sample Identification

·    0°C to 40°C

·    Bulk Packed per 500, racked per 25  

·    Maximum Recommended RCF Rating (50mL): 9400 xg

·    Maximum Recommended RCF Rating (15mL): 8400 xg

 

Code Product Name Quantity Price
oct-51 15ml Centrifuge Tubes, Sterile,Flat-top cap 500 47€
oct-01 50ml Centrifuge Tubes, Sterile,Flat-top cap 500 62€

 

Protein Extraction Tubes

 

The GeBAflex-tubes are the most efficient, user- friendly dialysis & buffer exchange tool in the market today.
Experience the comfort of standard pipette loading and unloading, wide range of volumes & MWCO and a 98% sample recovery yield, all at affordable prices.

Owing to its revolutionary design the GeBAflex-tube is the only dialysis tool available which allows for true high throughput dialysis, accommodating a large number of samples in a single buffer tank.

The GeBAflex-tube allows rapid, high performance extraction of macromolecules without any contamination and is ideal for purification of proteins, automated protein sequencing, peptide mapping and amino acid analysis.

 Applications

·    Dialysis or buffer exchange of volumes between 10ml-20ml.

·    Preparation of protein samples for MALDI-MS.

·    Sample concentration.

·    Large-scale protein dialysis such as antibodies and recombinant protein purification.

·    Peptide dialysis small as 10 amino acids.

·    Virus-particle purification.

·    Removal of contaminating micro molecules.

·    Tissue culture extracts purification.

·    Removal of salts, surfactants, solvents and detergents.

·    Complex formation studies (protein-protein, protein-DNA and protein-RNA).

·    pH and buffer adjustment of sample solution, protein extract or cell extract.

·    High through put dialysis, a single beaker for several GeBAflex-tubes on one floating pad

 

Comes in 4 Sizes:

·    Mini: 10-250µl

·    Midi: 50-800µl

·    Maxi: 0.1-3ml

·    Maxi: 0.1-3ml

·    Mega: 3-20ml

Available MWCO:

·    1000

·    3500

·    6000-8000

·    12000-14000

·    25000

·    50000

 

 

Code Product Name Qty. Price
T010 Midi kit, 3500 cut-off 10 91€
T012 Midi kit, 3500 cut-off 30 152€
T021 Midi kit, 6000-8000 cut-off 15 105€
T055 Maxi kit, 12000-14000 cut-off 15 102€
D010 Midi kit, 3500 cut-off 10 70€
D020 Midi kit, 6000-8000 cut-off 10 70€
D022 Midi kit, 6000-8000 cut-off 30 112€
D030 Maxi kit, 3500 cut-off 5 61€
D045 Maxi kit, 6000-8000 cut-off 15 91€
D055 Maxi kit, 12000-14000 cut-off 15 91€
D080-6 Mega kit, 6000-8000 cut-off 10 43€

More information on www.gentaur.com

Page 8

 

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Last modified: 06/25/09