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 rHuIL-2-3MIU huIFNa-2a huIFNa-2b Mouse GM-CSF rHuIL-4 GMPhuIL-4-50µg RHUGMCSF-300µg RHUGM-CSF-50µg huG-CSF-300µg huIL-6 -50 µg rhug-csf 300µg rhug-csf_75µg rhuil-1b-100µg

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Filgrastim (rHuG-CSF)

 

 

l        Description

Filgrastim is a human granulocyte colony stimulating factor (G-CSF), produced by recombinant DNA technology by E.coli. It is 175 amino acid protein, non-glycosylated, and has a molecular weight of approximately 18.8kD. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine necessary for expression in E. coli.

 

l        Indication

1.        Neutropenia resulting from cancer chemotherapy.

2.        Neutrophil decrease after bone marrow transplantation.

3.        Neutropenia caused by Myelodysplastic syndrome, neutropenia caused by aplastic anemia; congenital neutropenia, idiopathic neutropenia, Myelodysplastic syndrome with neutropenia and Periodic neutropenia.

4.        Patients undergoing peripheral blood progenitor cell collection and therapy.

 

l        Pharmaceutical particulars

Sterile, clear, colorless and preservative-free liquid for injection in vial

Dosage: 75μg/vial, 150μg/vial, 300μg/vial and 480μg/vial

Reference: Chinese Pharmacopoeia

Specific activity: ≥0.8×108IU/mg
Purity
(HPLC, SDS-PAGE): ≥98%

 

l        Composition

 Active ingredients: Filgrastim (rHuG-CSF).

 Inactive ingredients: Glacial Acetic Acid, Mannitol, Polysorbate 80 and Sodium Acetate.

 

l        Shelf life and storage conditions

 

 Finished formulation

 Store at 2-8 for 2 years

 API (Concentrated solution)

 Store at 2-8 for 7 months

 

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Last modified: 06/25/09